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pentobarbital will lessen the level or influence of netupitant/palonosetron by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Netupitant is principally metabolized by CYP3A4; avoid use in patients who are chronically using a solid CYP3A4 inducerPentobarbital belongs to a class of prescription drugs ofte